2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Names and Identifiers

Name	Tenofovir disoproxil fumarate
Synonyms	Aids031697 Aids-031697 Bis(neopentyloc)pmpa Tenofovir disoproxil fumarate Tenofovir diisoproxil fuMarate Tenofovir dipivoxil FuMarate(TDF) Tenofovir Disoproxil Fumarate (200 mg) 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate bis({[(1-methylethoxy)carbonyl]oxy}methyl) {[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonate (2E)-but-2-enedioate 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate
CAS	202138-50-9
EINECS	687-766-5
InChI	InChI=1/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Physico-chemical Properties

Molecular Formula	C23H34N5O14P
Molar Mass	635.52
Melting Point	113-115°C
Boling Point	642.7°C at 760 mmHg
Flash Point	342.5°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	2.06E-16mmHg at 25°C
Appearance	White to pink crystals
Color	white to beige
Storage Condition	2-8°C
In vitro study	The circulation of Tenofovir is actively secreted by the kidneys through glomerular filtration and renal tubules. Tenofovir is not a substrate for human organic cation transport type 1 (hOCT1) or hoct2. In MRP4 overexpressing cells, Tenofovir accumulates to five-fold lower levels, and MRP inhibitors can increase its accumulation. Tenofovir does not significantly affect mitochondrial DNA(mtDNA) in human hepatoblastoma (HCC) cells, skeletal muscle cells (SkMCs) or renal proximal tubule epithelial cells. In HepG2 cells or SkMCs, Tenofovir increased lactate production by less than 20%. Tenofovir is a potent phosphorylation of Tenofovir diphosphate (TFV-DP) in HepG2 cells and human primary hepatocytes. In the cell-based assay, the 50% effective concentration of Tenofovir anti-HBV was 1.1 mM, with a 50-fold increase in efficiency after the addition of the pre-bis-isoproxil group. In Vitro and clinically, Tenofovir has full activity against lamivudine-resistant HBV. Tenofovir inhibited the proliferation of hepatogenic hepatocellular carcinoma cells and normal skeletal muscle cells with CC(50) values of 398 μm and 870 μm, respectively. Tenofovir has a weaker effect than cidofovir on the proliferation and viability of renal proximal tubular epithelial cells, and cidofovir has a potential related nucleotide analog to induce renal tubular dysfunction.

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
HS Code	2933599550

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Reference

Reference

1. Yan Pengfei, Cui Yixuan, Liu Di et al.. Determination of 9-propenyladenine in tenofovir disoproxil fumarate by dispersion liquid-liquid microextraction combined with HPLC [J]. Analysis Laboratory 2019 v.38(12):58-61.
2. [IF = 3.414] Qing Zhao et al."Effects of traditional Chinese medicine formula Le-Cao-Shi on hepatitis B: in vivo and in vitro studies." J Ethnopharmacol. 2019 Nov;244:112132

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-

Nantong Reform Petro-Chemical CO., LTD.

Spot supply

Product Name: Tenofovir disoproxil fumarate Request for quotation
CAS: 202138-50-9
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865

Send QQ message

Hubei YoungXin Pharmaceutical Tech Co.,Ltd.

Spot supply

Product Name: Tenofovir Disoproxil Fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Jiangsu Pules Biotechnology Co.,Ltd.

Product Name: Tenofovir disoproxil fumarate Request for quotation
CAS: 202138-50-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756

Shanghai Yuanye Bio-Technology Co., Ltd.

Spot supply

Product Name: Tenofovir Disoproxil Fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Nantong Reform Petro-Chemical CO., LTD.

Spot supply

Product Name: Tenofovir disoproxil fumarate Request for quotation
CAS: 202138-50-9
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865

Send QQ message

Hubei YoungXin Pharmaceutical Tech Co.,Ltd.

Spot supply

Product Name: Tenofovir Disoproxil Fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Jiangsu Pules Biotechnology Co.,Ltd.

Product Name: Tenofovir disoproxil fumarate Request for quotation
CAS: 202138-50-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756

Shanghai Yuanye Bio-Technology Co., Ltd.

Spot supply

Product Name: Tenofovir Disoproxil Fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-

Tenofovir disoproxil fumarate

CAS: 202138-50-9

Molecular Formula: C23H34N5O14P

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Names and Identifiers

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Physico-chemical Properties

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Risk and Safety

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Reference

Supplier List

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- Request for Quotation

Tenofovir disoproxil fumarate

CAS: 202138-50-9

Molecular Formula: C23H34N5O14P

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Names and Identifiers

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Physico-chemical Properties

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Risk and Safety

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)- - Reference

Supplier List

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-